NanoTME 2023 · 2nd edition

Program

8 — 10 May
UPark, University of Twente

The first in-person edition of the conference, hosted on the campus of the University of Twente in Enschede and organised in collaboration with the International Cancer Microenvironment Society. The full scientific programme is reproduced below.

Monday 8 May

9:00–10:30 — Registration and coffee/tea. 10:30–10:50 — Opening by Jai Prakash and Yuval Shaked.

Extracellular Matrix in the TME

Chair: Kristian Pietras

• 10:50–11:25 — Viola Vogel (Keynote): How is the mechanobiology of ECM altered in cancer?
• 11:25–11:50 — Thomas Cox: Deconstructing Solid Tumour Heterogeneity: The Matrix Perspective
• 11:50–12:15 — Gertraud Orend: Targeting tenascin-c in cancer
• 12:15–12:30 — Short talk selected from abstracts — Karina Benderski: Monitoring the effect of the fibrotic tumor microenvironment on tumor-targeted drug delivery in immunocompetent mouse models
• 12:30–13:45 — Lunch

Tumor immune microenvironment

Chair: Helena Florindo

• 13:45–14:10 — Peter Friedl: Tumor microenvironment and nutrient deprivation: plasticity of biomechanics, invasion and metastasis
• 14:10–14:35 — Helder Santos: Smart Nanoparticle-based Platforms for Regulating Tumor Microenvironment and Cancer Immunotherapy
• 14:35–15:00 — Short talks selected from abstracts — Bram Priem: Systemically inducing trained immunity overcomes local immunosuppression in the tumor microenvironment; Ari Glasner: Designing rational Treg and tumor microenvironment-based therapies in lung cancer
• 15:00–15:30 — Tea/Coffee Break

The TME and therapy resistance

Chair: Yuval Shaked

• 15:30–15:55 — Yuval Shaked: A subset of neutrophils as a potential biomarker for immunotherapy response
• 15:55–16:20 — Jonathan Sleeman: Resistance of melanoma to combined braf/mek targeted therapy is mediated by drug tolerant persister cells that engage in extensive ECM remodelling
• 16:20–17:00 — Short talks selected from abstracts — Beata Pyrzynska: Cation carriers as prospective drug candidates for overcoming lymphoma resistance to therapeutic monoclonal antibodies; Rotem Menachem: Bone marrow targeted lipid nanoparticles to overcome multiple myeloma resistance; Alessio Malfanti: In situ administration of sting-activating hyaluronic acid-conjugate primes robust anti-glioblastoma immune response
• 18:30–22:00 — Dinner and poster visits

Tuesday 9 May

Nanomedicine – TME interactions. Chair: Thomas Cox

• 09:00–09:35 — Avi Schroeder (Keynote): Nanotechnology drugs efficiency is affected by the tumor microenvironment and the gender of the patient
• 09:35–10:00 — Helena Florindo: Regulation of tumor microenvironment immune profile using nanomedicines
• 10:00–10:30 — Short talks selected from abstracts — Quim Pena: Developing tumor microenvironment-activatable (metallo)prodrugs for cancer nanotherapy; Mingchao Wang: Doxorubicin lauroyl hydrazone derivative lipid nanocapsule based injectable hydrogel to inhibit gbm recurrences
• 10:30–11:00 — Tea/Coffee Break

TME Heterogeneity and cell metabolism

Chair: Gertraud Orend

• 11:00–11:25 — Kristian Pietras: Exploring the organizational principles of the tumor microenvironment to reveal functional heterogeneity
• 11:25–11:50 — Sara Zanivan: Tinkering with CAF metabolism to establish an anti-tumour stroma
• 11:50–12:15 — Maarten Bijlsma: Stromal contributions to stem cell functionality in pancreatic cancer
• 12:15–12:30 — Short talk selected from abstracts — Turkowski Kati: Single-cell RNA sequencing reveals heterogeneity and plasticity of Tumor associated macrophages in lung cancer
• 12:30–13:45 — Lunch and group photo

Targeting tumor immune microenvironment

Chair: Sjoerd Hak

• 13:45–14:10 — Roy van der Meel: Engineering platform NANOtechnology for RNA delivery to immune cells
• 14:10–14:35 — Alexandros Sofias: Nanomedicine hitchhiking with immune cells
• 14:35–15:00 — Short talks selected from abstracts — Flavia Moreira de Sousa: Intratumoral IL-12 delivery through nanoparticles empowers glioblastoma immunotherapy; Kunal Pednekar: Inhibition of immune suppression by targeting tumor-associated macrophages using “tail-flipping” nanoliposomes
• 15:00–15:30 — Tea/Coffee Break

Imaging and diagnostic tools for TME

Chair: Roy van der Meel

• 15:30–15:55 — Miles Miller: Imaging bio-orthogonal nanotherapy in the TME: from catalysis to radiation
• 15:55–16:20 — Rajkumar Savai: Spatial temporal dynamics and spatial immune phenotypic signature in lung tumor microenvironment

Special Talks

16:30–17:30

• Sjoerd Hak: Nanomedicine at SINTEF
• Simon Drescher: The Phospholipid Research Center Heidelberg – An Introduction
• Mike de Leeuw: OncoLize
• Jos Olijve: Endotoxin contamination alters macrophage-cancer cell interaction and therapeutic efficacy in pre-clinical 3D in-vitro models
• 18:30–20:30 — Dinner
• 20:30–22:00 — Poster Presentation

Wednesday 10 May

Nanomedicines towards clinic. Chair: Peter Friedl

• 09:00–09:35 — Jolanda de Vries (Keynote): PLGA nanoparticles co-encapsulating NY-ESO-1 peptides and IMM60 induce robust CD8 and CD4 T cell and B cell responses
• 09:35–10:00 — Alberto Gabizon: Harnessing nanomedicine to enhance tumor accumulation and potentiate the effects of chemotherapy and aminobisphosphonates
• 10:00–10:30 — Short talks selected from abstracts — Myrofora Panagi: Translational nanomedicine NC-6300 improves immunotherapy by normalizing the tumor microenvironment in metastatic sarcoma; Anne Seynhaeve: Tumor vessel abnormalization to improve nanoparticle delivery: investigating the role of pericytes
• 10:30–11:00 — Tea/Coffee Break

Targeting the tumor stroma

Chair: Jai Prakash

• 11:00–11:25 — Luuk Hawinkels: Cancer-associated fibroblasts as key determinants of tumor invasion in the earliest (T1) colorectal cancer stage
• 11:25–11:50 — Jai Prakash: Nanomedicine strategies to target tumor stroma
• 11:50–12:05 — Short talk selected from abstracts — Antonia Charalambous: Tumour microenvironment reprogramming improves nano-immunotherapy in a mouse fibrosarcoma model
• 12:05–13:30 — Lunch

3D Bioengineered models for TME

Chair: Alexandros Sofias

• 13:30–13:55 — Subhash Kundu: Biomaterials and on-chip solutions to mimic and study the tumor microenvironment
• 13:55–14:20 — Bart Kramer (Mimetas): Modeling the tumor microenvironment on-a-chip
• 14:20–14:35 — Short talk selected from abstracts — Oommen O. Podiyan: Immunoresponsive hydrogel scaffold for disease modeling and tissue engineering
• 14:35–15:00 — Poster Prize announcement and end of the conference